CJC-1295/Ipamorelin
Growth Hormone Optimization
The synergistic peptide combination for natural GH elevation, enhanced recovery, improved body composition, and anti-aging benefits.
What is CJC-1295/Ipamorelin?
CJC-1295 and Ipamorelin are two peptides that work synergistically to stimulate the natural production and release of growth hormone (GH) from the pituitary gland. This combination is one of the most popular peptide stacks in the biohacking and longevity communities.
CJC-1295 is a Growth Hormone Releasing Hormone (GHRH) analog that increases the amplitude of GH pulses. It has a longer half-life, providing sustained GH elevation.
Ipamorelin is a Growth Hormone Secretagogue (GHS) that increases the frequency of GH pulses. It's highly selective and doesn't significantly affect cortisol or prolactin levels.
Key Benefits
Muscle Growth & Recovery
Enhanced protein synthesis, faster recovery from training, and improved muscle mass retention
Fat Loss
Increased lipolysis (fat breakdown) and improved body composition without muscle loss
Sleep Quality
Deeper, more restorative sleep cycles leading to better recovery and cognitive function
Skin & Hair
Improved skin elasticity, reduced wrinkles, and healthier hair growth
Bone Density
Enhanced bone mineral density and reduced risk of osteoporosis
Anti-Aging
Cellular regeneration, improved vitality, and overall longevity support
Mechanism of Action
CJC-1295 and Ipamorelin are synergistic growth hormone secretagogues that stimulate endogenous growth hormone (GH) production through complementary mechanisms, creating a sustained and pulsatile GH release pattern that mimics natural physiological secretion.
Cellular-Level Functions
1. CJC-1295: GHRH Analog with Extended Half-Life
CJC-1295 is a modified growth hormone-releasing hormone (GHRH) analog that binds to GHRH receptors on somatotroph cells in the anterior pituitary gland. The Drug Affinity Complex (DAC) modification prevents enzymatic degradation by dipeptidyl peptidase-IV (DPP-IV), extending the half-life from minutes to approximately 6-8 days. This prolonged activity maintains elevated baseline GH levels and amplifies the amplitude of natural GH pulses without disrupting circadian rhythm.
2. Ipamorelin: Selective Ghrelin Receptor Agonist
Ipamorelin is a pentapeptide that selectively binds to ghrelin receptors (GHS-R1a) on pituitary somatotrophs, triggering calcium influx and cAMP-mediated signaling cascades that stimulate GH secretion. Unlike other ghrelin mimetics, Ipamorelin exhibits high selectivity for GH release without significantly affecting cortisol, prolactin, or ACTH levels, minimizing unwanted side effects while creating distinct GH pulses.
3. Synergistic GH Release Pattern
When combined, CJC-1295 provides sustained GHRH receptor activation (maintaining GH secretory capacity), while Ipamorelin delivers discrete GH pulses (mimicking natural pulsatile release). This combination produces higher peak GH levels than either compound alone, optimizing downstream IGF-1 production in the liver and peripheral tissues.
4. IGF-1 Mediated Anabolic Effects
Elevated GH stimulates hepatic and peripheral IGF-1 (insulin-like growth factor-1) synthesis. IGF-1 activates PI3K/Akt and MAPK signaling pathways in target tissues, promoting protein synthesis in muscle, stimulating chondrocyte proliferation in bone and cartilage, enhancing lipolysis in adipose tissue, and supporting cellular repair and regeneration throughout the body.
5. Metabolic Regulation
GH and IGF-1 shift metabolism toward anabolism by increasing glucose uptake in muscle, enhancing lipolysis and fatty acid oxidation, improving insulin sensitivity in non-adipose tissues, and promoting nitrogen retention and protein synthesis. This metabolic shift supports body recomposition, improved recovery, and enhanced physical performance.
Clinical Relevance: The CJC-1295/Ipamorelin combination replicates youthful GH secretion patterns without the risks associated with exogenous GH administration. By preserving natural pulsatility and avoiding supraphysiological peaks, this protocol supports physiological adaptation, minimizes receptor desensitization, and maintains feedback regulation of the GH/IGF-1 axis.
Starter Protocol
Conservative Starter Dose
- Dosage: 100 mcg per injection (conservative starting point)
- Frequency: 5-7 times per week
- Timing: On an empty stomach, at least 30 minutes before eating. Optimal timing is before bed to align with natural GH pulse.
- Administration: Subcutaneous injection (abdomen, thigh, or upper arm)
Personalized Protocols: Dosing frequency, injection timing, cycle length, and titration strategies vary significantly based on individual goals, body composition, training status, and metabolic response. Work with Tide Wellness coaching team to develop advanced protocols tailored to your specific needs—whether targeting muscle growth, fat loss, recovery optimization, or anti-aging.
Reconstitution Instructions
- Use bacteriostatic water for reconstitution
- Add 2ml of bacteriostatic water to the 10mg vial
- Gently swirl (do not shake) until powder is fully dissolved
- Store in refrigerator (2-8°C) for up to 30 days
- Each 0.1ml contains approximately 500mcg
Note: This information is for research purposes only. Always consult with a qualified healthcare professional before starting any peptide protocol.
Frequently Asked Questions
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