NAD+ 500mg
Cellular Energy & Longevity
The foundational molecule for cellular energy production, DNA repair, and healthy aging. NAD+ levels naturally decline with age—supplementation restores them.
Key Benefits
Mechanism of Action
NAD+ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme present in every cell, serving as a critical electron carrier in cellular energy production and a substrate for enzymes regulating cellular health and longevity.
Cellular-Level Functions
1. Mitochondrial Energy Production
NAD+ is the primary electron acceptor in the electron transport chain, directly enabling ATP synthesis. Each glucose molecule requires NAD+ at multiple steps of glycolysis and the citric acid cycle, making it indispensable for cellular energy metabolism.
2. Sirtuin Activation
NAD+ is the obligate substrate for sirtuins (SIRT1-7), a family of NAD+-dependent deacetylases that regulate gene expression, DNA repair, mitochondrial biogenesis, and cellular stress resistance. Sirtuins consume NAD+ to remove acetyl groups from histones and other proteins, modulating cellular metabolism and longevity pathways.
3. DNA Repair via PARPs
Poly(ADP-ribose) polymerases (PARPs) use NAD+ to repair DNA damage by adding ADP-ribose chains to nuclear proteins. This process is critical for maintaining genomic stability but depletes NAD+ pools, particularly under oxidative stress.
4. Cellular Signaling
NAD+ serves as a substrate for CD38 and other NAD+ glycohydrolases that generate calcium-mobilizing second messengers, regulating immune function, inflammation, and metabolic signaling.
Age-Related Decline: NAD+ levels decline approximately 50% between ages 20 and 50 due to increased consumption by DNA repair enzymes, reduced biosynthesis, and elevated degradation by CD38. This decline correlates with decreased mitochondrial function, impaired DNA repair capacity, reduced sirtuin activity, and accumulation of cellular damage—hallmarks of biological aging.
NAD+ supplementation restores these levels, supporting mitochondrial function (your cellular powerhouses), activating sirtuins (longevity proteins), and enhancing DNA repair mechanisms. The result: more energy, better recovery, sharper cognition, and support for healthy aging.
Starter Protocol
Conservative Starter Dose
50mg per dose, 2-3 times per week. This conservative starting point allows you to assess individual tolerance and response. Work with Tide Wellness coaching team to develop personalized advanced protocols tailored to your specific goals, tolerance, and metabolic response.
Timing
Morning or early afternoon for energy boost. Can also be used before workouts for enhanced performance or after alcohol consumption for recovery support.
Stacking
Pairs well with CJC-1295/Ipamorelin for comprehensive performance optimization, or with KLOW for enhanced recovery and longevity support.
Personalized Protocols
Cycle length, dosing frequency, and titration strategies vary significantly based on individual goals and response. Tide Wellness provides comprehensive coaching to design optimal protocols for your specific needs, whether targeting acute performance, recovery support, or long-term longevity optimization.
Frequently Asked Questions
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